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The genetic engineering of human lymphocytes as a potential therapy for inherited, acquired or infectious disease requires efficient transfer and expression of the transgene. In the case of adoptive immunotherapy for cancer, naturally occurring antitumor T-cell receptors (TCRs) have been used to endow normal T cells with antitumor reactivity.1 In a recent clinical trial, we demonstrated the successful conferral of antitumor function through ex vivo -retroviral transduction of a MART-1-reactive T… Continue